Protein Structure Determination, Fall 2020

Meets Mon/Thurs 10-11:50 in CII-3039
Office hours Wednesday 10-12 via Webex (check your email)

Syllabus for 2020


Homework upload page


Videos page


Lectures

√∅ Slides Title     When Reading Due
Lecture 1 Overview: crystals and symmetry  PDF  Mon, Oct. 19      
Lecture 2 The scattering of X-rays by electrons.  PDF  Thu, Oct. 22  Ch 3, 5, 6.2  Ex 1  
Lecture 3 Bragg’s law. Diffraction.  PDF  Mon, Oct. 26  Ch 4, 7.5.3  Ex 2  
Lecture 4 The Reciprocal lattice.  PDF  Thu, Oct. 29  Ch 6.3-6.3.2  HW1  
Lecture 5 Phasing. Isomorphous replacement.  PDF  Mon, Nov. 2  Ch 6.3.3, 6.4  Ex 3  
Lecture 6 Anomalous scattering.  PDF  Thu, Nov. 5  Ch. 6.5-7.4  Ex 4  
Lecture 7 Molecular replacement.  PDF  Mon, Nov. 9  Ch 7.5-8.2  Ex 5  
Lecture 8 Model building. Manual refinement.  PDF  Thu, Nov. 12  Coot, CCP4  HW2  
Lecture 9 Automated Refinement. B-factors.  PDF  Mon, Nov. 16  Ch 7.7, 8.3  Ex 6  
Lecture 10 Model validation.  PDF  Thu, Nov. 19    Ex 7  
Lecture 11 Laue photography and MicroED  PDF  Mon, Nov. 23  Ch 9.5-6  Ex 8  
    Thanksgiving. No class.    Thu, Nov. 26      
Lecture 12 review session, students present  PDF  Mon, Nov. 30      
Lecture 13 review session, office hour style  PDF  Thu, Dec 3      
Lecture 14 Student presentations  PDF  Mon, Dec 7      
Lecture 15 Student presentations  PDF  Mon, Dec 10      
    final exam (Xray only)    Tue, Dec 15 10:10am      
Go to Prof Wang's course page

Links etc

 Syllabus   Unix stuff  Download Jmol Download XrayView Download CCP4
 JQquestion   Bragg Planes (java)   Homework 4 
 Homework 5   Term Project   Get a PDB file   Homework 6   Homework X 
 short course 1   short course 2   MolProbity   Escher web sketch 
 Coot tutorial   Full Xray data set (716 Mb zip file) 
 Fobs map   Unrefined coordinates   Spacegroup images  Crystal math 
 COOT tutorial PDB file   COOT tutorial MTZ file   Ex 8 paper 
 PDB for Phenix  MTZ for Phenix  SEQ for Phenix
 4m6k  7dfr

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Last updated Mon Nov 23 14:50:07 EST 2020 Mon Oct 12 08:58:49 EDT 2020 W3C validation